It was only about a week ago that the U.S. Food and Drug Administration revoked the approval of Avastin® (bevacizumab) as a treatment for breast cancer.  This is not the end of the world for the Genentech, who was acquired by the Roche Holdings (OTCQX:RHHBY) for $46.8 billion in March of 2009, drug as it still retained its indications for colon, kidney, lung and brain cancer.  The revocation did, however, increase awareness for other breast cancer treatment candidates coming down the pipeline. Read More

Clearance of Sunshine Biopharma’s anti-cancer compound, Adva-27a, does not involve a toxic intermediate -
Sunshine Biopharma Inc. (OTCBB:SBFM) a development stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed another study of the mechanism of clearance of its Adva-27a in human liver microsomes in vitro. In the present study, an analysis of the metabolic intermediates generated during the clearance process was performed.The study focused specifically on the generation of Podophyllotoxin, a potentially very toxic intermediate. In addition, the study was performed as a side-by-side experiment in which Adva-27a was compared to Etoposide, a commonly used Read More